MCAS Symptoms in Women: How Hormonal Changes Can Trigger Mast Cell Activation MCAS symptoms in women often worsen during perimenopause and menopause due to hormonal changes that affect mast cell stability. Mast Cell Activation Syndrome (MCAS) occurs when mast cells release inflammatory substances such as histamine inappropriately, leading to symptoms like flushing, itching, digestive discomfort, …

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